@article{du_vinyl_2025,
	title = {Vinyl cyclopropanes as a unifying platform for enantioselective remote difunctionalization of alkenes},
	volume = {16},
	issn = {2041-1723},
	url = {https://www.nature.com/articles/s41467-025-61363-3},
	doi = {10.1038/s41467-025-61363-3},
	abstract = {Abstract 
             
              Asymmetric remote difunctionalization of alkenes is a longstanding challenge in synthetic chemistry, offering the potential to install two functional groups simultaneously across distal carbon atoms in a stereocontrolled manner. While ingenious strategies have been devised to achieve this transformation, a general catalytic system for remote, enantioselective hetero-carbofunctionalization 
              and 
              dicarbofunctionalization of alkenes has remained elusive. Here, we present a nickel/photoredox dual-catalyzed asymmetric remote 1,5-carbosulfonylation and 1,5-dicarbofunctionalization of vinyl cyclopropanes. This cascade reaction integrates radical addition, C–C bond cleavage, and cross-coupling to functionalize two distal carbon atoms with high enantioselectivity. Our protocol demonstrates broad substrate scope, excellent functional group tolerance, and significant synthetic utility, as evidenced by late-stage functionalization and product derivatization. Our mechanistic investigations support the involvement of a Ni(0)/Ni(I)/Ni({III}) catalytic cycle in our system. This work establishes a versatile platform for remote alkene difunctionalization, expanding the toolbox of enantioselective synthetic methods and unlocking new avenues for complex molecule construction.},
	pages = {6958},
	number = {1},
	journaltitle = {Nature Communications},
	shortjournal = {Nat Commun},
	author = {Du, Xiaoyong and Lennon, Marc E. and Kriticou, Georgia and Nevado, Cristina},
	urldate = {2025-08-14},
	date = {2025-07-29},
	langid = {english},
}