@article{zhang_regulation_2025,
	title = {Regulation of the {cGAS}-{STING} Pathway},
	volume = {43},
	rights = {http://creativecommons.org/licenses/by/4.0/},
	issn = {0732-0582, 1545-3278},
	url = {https://www.annualreviews.org/content/journals/10.1146/annurev-immunol-101721-032910},
	doi = {10.1146/annurev-immunol-101721-032910},
	abstract = {The {cGAS}-{cGAMP}-{STING} pathway is essential for immune defense against pathogens. Upon binding {DNA}, {cGAS} synthesizes {cGAMP}, which activates {STING}, leading to potent innate immune effector responses. However, lacking specific features to distinguish between self and nonself {DNA}, {cGAS}-{STING} immunity requires precise regulation to prevent aberrant activation. Several safeguard mechanisms acting on different levels have evolved to maintain tolerance to self {DNA} and ensure immune homeostasis under normal conditions. Disruption of these safeguards can lead to erroneous activation by self {DNA}, resulting in inflammatory conditions but also favorable antitumor immunity. Insights into structural and cellular checkpoints that control and terminate {cGAS}-{STING} signaling are essential for comprehending and manipulating {DNA}-triggered innate immunity in health and disease.},
	pages = {667--692},
	number = {1},
	journaltitle = {Annual Review of Immunology},
	author = {Zhang, Bing and Xu, Pengbiao and Ablasser, Andrea},
	urldate = {2025-05-22},
	date = {2025-04-25},
	langid = {english},
}