%0 Journal Article
%T Vinyl cyclopropanes as a unifying platform for enantioselective remote difunctionalization of alkenes
%V 16
%N 1
%P 6958
%U https://www.nature.com/articles/s41467-025-61363-3
%X Abstract 
             
              Asymmetric remote difunctionalization of alkenes is a longstanding challenge in synthetic chemistry, offering the potential to install two functional groups simultaneously across distal carbon atoms in a stereocontrolled manner. While ingenious strategies have been devised to achieve this transformation, a general catalytic system for remote, enantioselective hetero-carbofunctionalization 
              and 
              dicarbofunctionalization of alkenes has remained elusive. Here, we present a nickel/photoredox dual-catalyzed asymmetric remote 1,5-carbosulfonylation and 1,5-dicarbofunctionalization of vinyl cyclopropanes. This cascade reaction integrates radical addition, C–C bond cleavage, and cross-coupling to functionalize two distal carbon atoms with high enantioselectivity. Our protocol demonstrates broad substrate scope, excellent functional group tolerance, and significant synthetic utility, as evidenced by late-stage functionalization and product derivatization. Our mechanistic investigations support the involvement of a Ni(0)/Ni(I)/Ni(III) catalytic cycle in our system. This work establishes a versatile platform for remote alkene difunctionalization, expanding the toolbox of enantioselective synthetic methods and unlocking new avenues for complex molecule construction.
%G en
%J Nature Communications
%A Du, Xiaoyong
%A Lennon, Marc E.
%A Kriticou, Georgia
%A Nevado, Cristina
%D 2025-07-29